Interazioni tra farmaci
Fentanyl + Olanzapine / samidorphan
Gravità: Controindicata
Fentanyl and Olanzapine / samidorphan: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Samidorphan blocks opioid receptors, reducing fentanyl's analgesic effect and potentially precipitating withdrawal in opioid-dependent patients. Attempts to overcome the blockade with higher opioid doses risk overdose.
Cosa significa questa interazione in parole semplici
Fentanyl and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Samidorphan is a mu-opioid receptor antagonist that opposes fentanyl's agonist effects.
Cosa fare
Ensure an opioid-free interval of at least 7 days for short-acting and 14 days for long-acting opioids before starting. Use an alternative antipsychotic in patients who need opioids.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fentanyl
- Alvimopan + Fentanyl Controindicata
- Fentanyl + Isocarboxazid Controindicata
- Fentanyl + Phenelzine Controindicata
- Fentanyl + Tranylcypromine Controindicata
- Alfentanil + Fentanyl Maggiore
- Alprazolam + Fentanyl Maggiore
Domande frequenti
Can I take Fentanyl with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Fentanyl and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan blocks opioid receptors, reducing fentanyl's analgesic effect and potentially precipitating withdrawal in opioid-dependent patients. Attempts to overcome the blockade with higher opioid doses risk overdose.
How serious is the interaction between Fentanyl and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure an opioid-free interval of at least 7 days for short-acting and 14 days for long-acting opioids before starting. Use an alternative antipsychotic in patients who need opioids.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Phenelzine. The full list is on the Fentanyl page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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