Interazioni tra farmaci
Fentanyl + Phenelzine
Gravità: Controindicata
Fentanyl and Phenelzine: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Phenelzine irreversibly blocks MAO-A and MAO-B, and fentanyl is a serotonergic opioid. Serotonin syndrome or an excitatory/depressive MAOI-opioid reaction (hypertension or profound respiratory depression) may result.
Cosa significa questa interazione in parole semplici
Fentanyl and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fentanyl belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.
Perché avviene
MAO inhibition with serotonergic opioid effect
Cosa fare
Avoid fentanyl within 14 days of an MAOI; if opioid is essential, use the lowest dose with close monitoring.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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- Additional notes
- Evidence detail
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Altre interazioni di Fentanyl
- Alvimopan + Fentanyl Controindicata
- Fentanyl + Isocarboxazid Controindicata
- Fentanyl + Olanzapine / samidorphan Controindicata
- Fentanyl + Tranylcypromine Controindicata
- Alfentanil + Fentanyl Maggiore
- Alprazolam + Fentanyl Maggiore
Altre interazioni di Phenelzine
- 5-HTP + Phenelzine Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amoxapine + Phenelzine Controindicata
- Atomoxetine + Phenelzine Controindicata
- Benzphetamine + Phenelzine Controindicata
- Brimonidine + Phenelzine Controindicata
Domande frequenti
Can I take Fentanyl with Phenelzine?
MediHelp rates the interaction as contraindicated. Fentanyl and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine irreversibly blocks MAO-A and MAO-B, and fentanyl is a serotonergic opioid. Serotonin syndrome or an excitatory/depressive MAOI-opioid reaction (hypertension or profound respiratory depression) may result.
How serious is the interaction between Fentanyl and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid fentanyl within 14 days of an MAOI; if opioid is essential, use the lowest dose with close monitoring.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
