Interazioni tra farmaci
Amikacin + Cefotaxime
Gravità: Moderata
Amikacin and Cefotaxime: moderate interaction.
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Sintesi
Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern.
Cosa significa questa interazione in parole semplici
Amikacin and Cefotaxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Cefotaxime belongs to Anti Bacterial.
Perché avviene
Additive nephrotoxic potential, with aminoglycoside tubular toxicity possibly being aggravated by cephalosporins.
Cosa fare
Monitor serum creatinine and amikacin levels during combined therapy, and keep the aminoglycoside course as short as possible. Maintain hydration and avoid other nephrotoxins.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Cefotaxime
- Cefotaxime + Typhoid vaccine live Maggiore
- Cefotaxime + Cholera vaccine Moderata
- Cefotaxime + Dexamethasone-tobramycin Moderata
- Cefotaxime + Gentamicin Moderata
- Cefotaxime + Kanamycin Moderata
- Cefotaxime + Microbiota Moderata
Altre interazioni di Amikacin
- Amikacin + Cidofovir Controindicata
- Adefovir + Amikacin Maggiore
- Amikacin + Amphotericin b Maggiore
- Amikacin + Amphotericin b deoxycholate Maggiore
- Amikacin + Atracurium Maggiore
- Amikacin + Bacitracin Maggiore
Domande frequenti
Can I take Amikacin with Cefotaxime?
MediHelp rates the interaction as moderate. Amikacin and Cefotaxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern.
How serious is the interaction between Amikacin and Cefotaxime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels during combined therapy, and keep the aminoglycoside course as short as possible. Maintain hydration and avoid other nephrotoxins.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefotaxime page.
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