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Amiodarone + Sofosbuvir-velpatasvir

Gravità: Maggiore

Amiodarone and Sofosbuvir-velpatasvir: major interaction.

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Il contenuto clinico di questa pagina è disponibile solo in inglese.

Sintesi

Co-administration of sofosbuvir-containing regimens with amiodarone has been associated with severe symptomatic bradycardia, including fatal cases and pacemaker insertion. Risk appears higher with beta-blockers, cardiac disease or advanced liver disease.

Cosa significa questa interazione in parole semplici

Amiodarone and Sofosbuvir-velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amiodarone belongs to Cardiovascular; Sofosbuvir-velpatasvir belongs to Anti Virals.

Livello di evidenza: Moderate

Perché avviene

The mechanism is not established; an additive effect on cardiac conduction is suspected.

Cosa fare

Avoid the combination where possible; if unavoidable, monitor the patient with continuous cardiac monitoring in hospital for the first 48 hours, then check heart rate daily or self-monitor for the first 2 weeks.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Amiodarone with Sofosbuvir-velpatasvir?

MediHelp rates the interaction as major. Amiodarone and Sofosbuvir-velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Co-administration of sofosbuvir-containing regimens with amiodarone has been associated with severe symptomatic bradycardia, including fatal cases and pacemaker insertion. Risk appears higher with beta-blockers, cardiac disease or advanced liver disease.

How serious is the interaction between Amiodarone and Sofosbuvir-velpatasvir?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if unavoidable, monitor the patient with continuous cardiac monitoring in hospital for the first 48 hours, then check heart rate daily or self-monitor for the first 2 weeks.

What other medicines interact with Sofosbuvir-velpatasvir?

MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.

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