Drug interactions
Amisulpride + Arsenic trioxide
Severity: Contraindicated
Amisulpride and Arsenic trioxide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arsenic trioxide markedly prolongs the QT interval and has been linked to torsades de pointes. Adding amisulpride, which also prolongs QTc, increases the risk of life-threatening arrhythmia.
What this interaction means in plain words
Amisulpride and Arsenic trioxide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amisulpride belongs to Central Nervous System; Arsenic trioxide belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization through effects on cardiac ion channels such as hERG.
What to do
Avoid concurrent use and choose an alternative antipsychotic or antiemetic with lower QT risk. If unavoidable, monitor ECG continuously and keep potassium and magnesium in the normal range.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Amisulpride + Pimozide Contraindicated
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
- Arsenic trioxide + Hydroxychloroquine Contraindicated
Frequently asked questions
Can I take Amisulpride with Arsenic trioxide?
MediHelp rates the interaction as contraindicated. Amisulpride and Arsenic trioxide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide markedly prolongs the QT interval and has been linked to torsades de pointes. Adding amisulpride, which also prolongs QTc, increases the risk of life-threatening arrhythmia.
How serious is the interaction between Amisulpride and Arsenic trioxide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an alternative antipsychotic or antiemetic with lower QT risk. If unavoidable, monitor ECG continuously and keep potassium and magnesium in the normal range.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Disopyramide, Dofetilide. The full list is on the Amisulpride page.
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