Interazioni tra farmaci
Arsenic trioxide + Clomipramine
Gravità: Controindicata
Arsenic trioxide and Clomipramine: contraindicated interaction.
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Sintesi
Arsenic trioxide causes marked QT prolongation and has been linked to torsades de pointes. Clomipramine also prolongs QT, so the combination adds serious arrhythmic risk.
Cosa significa questa interazione in parole semplici
Arsenic trioxide and Clomipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Clomipramine belongs to Central Nervous System.
Perché avviene
Additive QT prolongation by effects on cardiac ion channels.
Cosa fare
Avoid the combination and use an antidepressant with minimal QT effect. If it cannot be avoided, use close ECG and electrolyte monitoring.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clomipramine
- Clomipramine + Dofetilide Controindicata
- Clomipramine + Droperidol Controindicata
- Clomipramine + Isocarboxazid Controindicata
- Clomipramine + Methylene blue Controindicata
- Clomipramine + Pentamidine Controindicata
- Clomipramine + Phenelzine Controindicata
Altre interazioni di Arsenic trioxide
- Amiodarone + Arsenic trioxide Controindicata
- Amisulpride + Arsenic trioxide Controindicata
- Arsenic trioxide + Dronedarone Controindicata
- Arsenic trioxide + Fluphenazine Controindicata
- Arsenic trioxide + Gemifloxacin Controindicata
- Arsenic trioxide + Hydroxychloroquine Controindicata
Domande frequenti
Can I take Arsenic trioxide with Clomipramine?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Clomipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes marked QT prolongation and has been linked to torsades de pointes. Clomipramine also prolongs QT, so the combination adds serious arrhythmic risk.
How serious is the interaction between Arsenic trioxide and Clomipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antidepressant with minimal QT effect. If it cannot be avoided, use close ECG and electrolyte monitoring.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Dofetilide, Droperidol, Isocarboxazid. The full list is on the Clomipramine page.
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