Interazioni tra farmaci
Amitriptyline + Fluticasone-vilanterol
Gravità: Maggiore
Amitriptyline and Fluticasone-vilanterol: major interaction.
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Sintesi
Amitriptyline can potentiate the cardiovascular effects of vilanterol, producing tachycardia, arrhythmia and blood pressure changes, and it also prolongs the QT interval. The product label advises extreme caution with tricyclic antidepressants.
Cosa significa questa interazione in parole semplici
Amitriptyline and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Fluticasone-vilanterol belongs to Respiratory.
Perché avviene
Tricyclic noradrenaline reuptake inhibition and QT prolongation add to beta-2 agonist cardiac stimulation.
Cosa fare
Monitor heart rate, blood pressure and ECG, especially at the start of treatment and in patients with cardiac disease. Correct electrolytes and consider alternative therapy if arrhythmia emerges.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Fluticasone-vilanterol
Altre interazioni di Amitriptyline
- Amitriptyline + Isocarboxazid Controindicata
- Amitriptyline + Methylene blue Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amitriptyline + Pimozide Controindicata
- Amitriptyline + Procarbazine Controindicata
- Amitriptyline + Safinamide Controindicata
Domande frequenti
Can I take Amitriptyline with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Amitriptyline and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amitriptyline can potentiate the cardiovascular effects of vilanterol, producing tachycardia, arrhythmia and blood pressure changes, and it also prolongs the QT interval. The product label advises extreme caution with tricyclic antidepressants.
How serious is the interaction between Amitriptyline and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, especially at the start of treatment and in patients with cardiac disease. Correct electrolytes and consider alternative therapy if arrhythmia emerges.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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