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Interazioni tra farmaci

Amitriptyline + Sufentanil

Gravità: Maggiore

Amitriptyline and Sufentanil: major interaction.

Ultimo aggiornamento Fonti: US FDA label

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Sintesi

Combining a tricyclic antidepressant with an opioid increases sedation and the risk of respiratory depression. Amitriptyline may also potentiate serotonergic and hypotensive effects.

Cosa significa questa interazione in parole semplici

Amitriptyline and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amitriptyline belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.

Livello di evidenza: Moderate

Perché avviene

Additive CNS and respiratory depression, with some serotonergic contribution.

Cosa fare

Use the lowest effective sufentanil dose and monitor respiratory rate, sedation level, and blood pressure. Have airway support and reversal agents available in procedural settings.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Riferimenti

Domande frequenti

Can I take Amitriptyline with Sufentanil?

MediHelp rates the interaction as major. Amitriptyline and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a tricyclic antidepressant with an opioid increases sedation and the risk of respiratory depression. Amitriptyline may also potentiate serotonergic and hypotensive effects.

How serious is the interaction between Amitriptyline and Sufentanil?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective sufentanil dose and monitor respiratory rate, sedation level, and blood pressure. Have airway support and reversal agents available in procedural settings.

What other medicines interact with Amitriptyline?

MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.

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