Interazioni tra farmaci
Amitriptyline + Thioridazine
Gravità: Controindicata
Amitriptyline and Thioridazine: contraindicated interaction.
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Sintesi
Thioridazine is a strong QT-prolonging antipsychotic, and amitriptyline adds further QT and conduction effects. The combination markedly increases the risk of torsades de pointes and sudden cardiac death.
Cosa significa questa interazione in parole semplici
Amitriptyline and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amitriptyline belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Perché avviene
Additive QT prolongation, with thioridazine also inhibiting CYP2D6 and raising amitriptyline levels.
Cosa fare
Do not combine these drugs; select an alternative antipsychotic or antidepressant with less cardiac liability.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Amitriptyline
- Amitriptyline + Isocarboxazid Controindicata
- Amitriptyline + Methylene blue Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amitriptyline + Pimozide Controindicata
- Amitriptyline + Procarbazine Controindicata
- Amitriptyline + Safinamide Controindicata
Altre interazioni di Thioridazine
- Abiraterone + Thioridazine Controindicata
- Adagrasib + Thioridazine Controindicata
- Amiodarone + Thioridazine Controindicata
- Amisulpride + Thioridazine Controindicata
- Amoxapine + Thioridazine Controindicata
- Anagrelide + Thioridazine Controindicata
Domande frequenti
Can I take Amitriptyline with Thioridazine?
MediHelp rates the interaction as contraindicated. Amitriptyline and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine is a strong QT-prolonging antipsychotic, and amitriptyline adds further QT and conduction effects. The combination markedly increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Amitriptyline and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine these drugs; select an alternative antipsychotic or antidepressant with less cardiac liability.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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