Interazioni tra farmaci
Amoxapine + Thioridazine
Gravità: Controindicata
Amoxapine and Thioridazine: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Both drugs can prolong the QT interval, and thioridazine carries a particularly high risk of torsades de pointes. Combining them also adds anticholinergic and sedative effects, and thioridazine can raise amoxapine levels.
Cosa significa questa interazione in parole semplici
Amoxapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Additive QT prolongation, with thioridazine inhibiting CYP2D6 metabolism of amoxapine.
Cosa fare
Avoid combining; choose an antidepressant with minimal QT effect. If previously combined, perform ECG and check electrolytes.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Thioridazine
- Abiraterone + Thioridazine Controindicata
- Adagrasib + Thioridazine Controindicata
- Amiodarone + Thioridazine Controindicata
- Amisulpride + Thioridazine Controindicata
- Amitriptyline + Thioridazine Controindicata
- Anagrelide + Thioridazine Controindicata
Domande frequenti
Can I take Amoxapine with Thioridazine?
MediHelp rates the interaction as contraindicated. Amoxapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and thioridazine carries a particularly high risk of torsades de pointes. Combining them also adds anticholinergic and sedative effects, and thioridazine can raise amoxapine levels.
How serious is the interaction between Amoxapine and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; choose an antidepressant with minimal QT effect. If previously combined, perform ECG and check electrolytes.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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