Interazioni tra farmaci
Amlodipine-hydrochlorothiazide-valsartan + Candesartan
Gravità: Maggiore
Amlodipine-hydrochlorothiazide-valsartan and Candesartan: major interaction.
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Sintesi
Candesartan is a second angiotensin receptor blocker given on top of valsartan, which provides dual renin-angiotensin system blockade without added benefit. This raises the risk of hypotension, hyperkalemia and renal impairment, although the thiazide component partly offsets potassium retention.
Cosa significa questa interazione in parole semplici
Amlodipine-hydrochlorothiazide-valsartan and Candesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Candesartan belongs to Cardiovascular.
Perché avviene
Duplicate angiotensin II type 1 receptor blockade produces additive hypotensive, potassium-retaining and renal hemodynamic effects.
Cosa fare
Avoid combining two ARBs and use a single agent at an appropriate dose. If it has happened, check potassium and creatinine promptly and stop one of the drugs.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Controindicata
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Controindicata
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Controindicata
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Maggiore
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Maggiore
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Maggiore
Altre interazioni di Candesartan
- Aliskiren + Candesartan Controindicata
- Candesartan + Sparsentan Controindicata
- Amifostine + Candesartan Maggiore
- Amiloride + Candesartan Maggiore
- Amlodipine-benazepril + Candesartan Maggiore
- Amlodipine-olmesartan-hydrochlorothiazide + Candesartan Maggiore
Domande frequenti
Can I take Amlodipine-hydrochlorothiazide-valsartan with Candesartan?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Candesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Candesartan is a second angiotensin receptor blocker given on top of valsartan, which provides dual renin-angiotensin system blockade without added benefit. This raises the risk of hypotension, hyperkalemia and renal impairment, although the thiazide component partly offsets potassium retention.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Candesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two ARBs and use a single agent at an appropriate dose. If it has happened, check potassium and creatinine promptly and stop one of the drugs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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