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Amlodipine-hydrochlorothiazide-valsartan + Dofetilide

Gravità: Controindicata

Amlodipine-hydrochlorothiazide-valsartan and Dofetilide: contraindicated interaction.

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Sintesi

Hydrochlorothiazide can raise dofetilide levels through reduced renal clearance and may also cause hypokalemia or hypomagnesemia. Higher dofetilide exposure prolongs the QT interval and can provoke torsades de pointes.

Cosa significa questa interazione in parole semplici

Amlodipine-hydrochlorothiazide-valsartan and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Dofetilide belongs to Cardiovascular.

Livello di evidenza: Moderate

Perché avviene

Thiazide-related reduction in renal elimination of dofetilide, with electrolyte disturbances adding to QT prolongation.

Cosa fare

Avoid concomitant use as labeled for dofetilide with thiazides; use an alternative antihypertensive. If therapy is essential, monitor QTc, potassium and magnesium closely.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Amlodipine-hydrochlorothiazide-valsartan with Dofetilide?

MediHelp rates the interaction as contraindicated. Amlodipine-hydrochlorothiazide-valsartan and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydrochlorothiazide can raise dofetilide levels through reduced renal clearance and may also cause hypokalemia or hypomagnesemia. Higher dofetilide exposure prolongs the QT interval and can provoke torsades de pointes.

How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Dofetilide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use as labeled for dofetilide with thiazides; use an alternative antihypertensive. If therapy is essential, monitor QTc, potassium and magnesium closely.

What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?

MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.

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