Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide
Severity: Contraindicated
Amlodipine-olmesartan-hydrochlorothiazide and Dofetilide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise dofetilide levels by reducing renal clearance and may cause hypokalemia or hypomagnesemia. Higher dofetilide exposure prolongs the QT interval and can provoke torsades de pointes.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Dofetilide belongs to Cardiovascular.
Why it happens
Thiazide-related reduction in renal elimination of dofetilide, with electrolyte disturbances adding to QT prolongation.
What to do
Avoid concomitant use and select a non-thiazide antihypertensive. If unavoidable, monitor QTc, potassium and magnesium closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan-hydrochlorothiazide and Dofetilide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amiloride + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Chloroquine + Dofetilide Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Dofetilide?
MediHelp rates the interaction as contraindicated. Amlodipine-olmesartan-hydrochlorothiazide and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydrochlorothiazide can raise dofetilide levels by reducing renal clearance and may cause hypokalemia or hypomagnesemia. Higher dofetilide exposure prolongs the QT interval and can provoke torsades de pointes.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Dofetilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select a non-thiazide antihypertensive. If unavoidable, monitor QTc, potassium and magnesium closely.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Sparsentan, Acemetacin. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
