Interazioni tra farmaci
Amoxapine + Linezolid
Gravità: Controindicata
Amoxapine and Linezolid: contraindicated interaction.
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Sintesi
Linezolid is a reversible nonselective MAO inhibitor and amoxapine inhibits serotonin and norepinephrine reuptake. Together they can precipitate serotonin syndrome with agitation, hyperthermia, clonus and autonomic instability.
Cosa significa questa interazione in parole semplici
Amoxapine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Additive serotonergic and noradrenergic effects from MAO inhibition plus reuptake inhibition.
Cosa fare
Avoid the combination and choose another antibiotic. If linezolid is essential, stop amoxapine and monitor closely for serotonin toxicity.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Linezolid
- Atomoxetine + Linezolid Controindicata
- Benzphetamine + Linezolid Controindicata
- Brimonidine + Linezolid Controindicata
- Bupropion-naltrexone + Linezolid Controindicata
- Bupropion + Linezolid Controindicata
- Buspirone + Linezolid Controindicata
Domande frequenti
Can I take Amoxapine with Linezolid?
MediHelp rates the interaction as contraindicated. Amoxapine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a reversible nonselective MAO inhibitor and amoxapine inhibits serotonin and norepinephrine reuptake. Together they can precipitate serotonin syndrome with agitation, hyperthermia, clonus and autonomic instability.
How serious is the interaction between Amoxapine and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antibiotic. If linezolid is essential, stop amoxapine and monitor closely for serotonin toxicity.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Atomoxetine, Benzphetamine, Brimonidine. The full list is on the Linezolid page.
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