Vai al contenuto
MediHelp
MediHelp Riferimento sui farmaci

Interazioni tra farmaci

Bupropion-naltrexone + Linezolid

Gravità: Controindicata

Bupropion-naltrexone and Linezolid: contraindicated interaction.

Ultimo aggiornamento

Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.

Il contenuto clinico di questa pagina è disponibile solo in inglese.

Sintesi

Linezolid is a reversible nonselective MAO inhibitor, and bupropion is contraindicated with MAO inhibitors because of the risk of hypertensive reactions and neurotoxicity. Serotonergic or noradrenergic excess can occur.

Cosa significa questa interazione in parole semplici

Bupropion-naltrexone and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Bupropion-naltrexone belongs to Miscellaneous; Linezolid belongs to Anti Bacterial.

Livello di evidenza: Moderate

Perché avviene

MAO inhibition by linezolid combined with bupropion's dopaminergic and noradrenergic reuptake inhibition causes catecholamine excess and possible serotonergic toxicity.

Cosa fare

Do not co-administer; use an alternative antibiotic. If linezolid is urgent, stop bupropion-naltrexone and monitor closely, and avoid restarting it until at least 24 hours after the last linezolid dose.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Per gli utenti Pro+

Sblocca la pagina completa

Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Bupropion-naltrexone e Linezolid, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Crea un account gratuito Accedi

Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.

Domande frequenti

Can I take Bupropion-naltrexone with Linezolid?

MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a reversible nonselective MAO inhibitor, and bupropion is contraindicated with MAO inhibitors because of the risk of hypertensive reactions and neurotoxicity. Serotonergic or noradrenergic excess can occur.

How serious is the interaction between Bupropion-naltrexone and Linezolid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an alternative antibiotic. If linezolid is urgent, stop bupropion-naltrexone and monitor closely, and avoid restarting it until at least 24 hours after the last linezolid dose.

What other medicines interact with Bupropion-naltrexone?

MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.

Monografie complete, posologie e verifica delle interazioni nell'app MediHelp

Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.

Scarica suApp Store Disponibile suGoogle Play

Sfoglia dalla A alla Z · Interazioni tra farmaci

Scarica l'app Accedi