Interazioni tra farmaci
Amoxicillin-clavulanic acid + Cholera vaccine
Gravità: Moderata
Amoxicillin-clavulanic acid and Cholera vaccine: moderate interaction.
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Sintesi
The oral live attenuated cholera vaccine relies on the vaccine strain colonizing the gut. Systemic antibiotics with activity against it may kill the strain and impair the immune response. Amoxicillin-clavulanate has activity against many Vibrio strains, so vaccine effectiveness could be reduced.
Cosa significa questa interazione in parole semplici
Amoxicillin-clavulanic acid and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Antibacterial activity against the live attenuated Vibrio cholerae vaccine strain reduces its replication and immunogenicity.
Cosa fare
Do not give the vaccine to patients who have taken systemic antibiotics in the preceding 14 days, per labeling. Avoid starting antibiotics for about 10 days after vaccination where possible, or revaccinate after the antibiotic course.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Domande frequenti
Can I take Amoxicillin-clavulanic acid with Cholera vaccine?
MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine relies on the vaccine strain colonizing the gut. Systemic antibiotics with activity against it may kill the strain and impair the immune response. Amoxicillin-clavulanate has activity against many Vibrio strains, so vaccine effectiveness could be reduced.
How serious is the interaction between Amoxicillin-clavulanic acid and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine to patients who have taken systemic antibiotics in the preceding 14 days, per labeling. Avoid starting antibiotics for about 10 days after vaccination where possible, or revaccinate after the antibiotic course.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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