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Amoxicillin-clavulanic acid + Methotrexate

Gravità: Maggiore

Amoxicillin-clavulanic acid and Methotrexate: major interaction.

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Sintesi

Penicillins can raise methotrexate concentrations and prolong exposure, leading to increased myelosuppression, mucositis and other toxicity. The effect is most concerning with high-dose methotrexate or impaired renal function.

Cosa significa questa interazione in parole semplici

Amoxicillin-clavulanic acid and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amoxicillin-clavulanic acid belongs to Anti Bacterial; Methotrexate belongs to Oncology.

Livello di evidenza: Moderate

Perché avviene

Competition for renal tubular secretion reduces methotrexate renal clearance.

Cosa fare

Monitor methotrexate levels, renal function and blood counts when co-administered, and consider an alternative antibiotic during high-dose methotrexate.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Amoxicillin-clavulanic acid with Methotrexate?

MediHelp rates the interaction as major. Amoxicillin-clavulanic acid and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Penicillins can raise methotrexate concentrations and prolong exposure, leading to increased myelosuppression, mucositis and other toxicity. The effect is most concerning with high-dose methotrexate or impaired renal function.

How serious is the interaction between Amoxicillin-clavulanic acid and Methotrexate?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor methotrexate levels, renal function and blood counts when co-administered, and consider an alternative antibiotic during high-dose methotrexate.

What other medicines interact with Amoxicillin-clavulanic acid?

MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Pexidartinib, Pretomanid, Allopurinol. The full list is on the Amoxicillin-clavulanic acid page.

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