Interazioni tra farmaci
Amphotericin b liposomal + Tenofovir disoproxil
Gravità: Moderata
Amphotericin b liposomal and Tenofovir disoproxil: moderate interaction.
Ultimo aggiornamento
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Sintesi
Both drugs can injure the kidney, and giving them together may add to the risk of renal impairment. Reduced kidney function can in turn raise tenofovir exposure and worsen tubular toxicity. The liposomal formulation is generally less nephrotoxic than conventional amphotericin B.
Cosa significa questa interazione in parole semplici
Amphotericin b liposomal and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Additive nephrotoxicity, with reduced renal clearance of tenofovir when kidney function declines.
Cosa fare
Monitor serum creatinine, estimated creatinine clearance, phosphate and electrolytes regularly during combined use. Adjust the tenofovir interval for renal function or choose an alternative if renal function falls.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Amphotericin b liposomal
- Amlodipine-benazepril + Amphotericin b liposomal Moderata
- Amphotericin b liposomal + Benazepril Moderata
- Amphotericin b liposomal + Captopril-hydrochlorothiazide Moderata
- Amphotericin b liposomal + Deflazacort Moderata
- Amphotericin b liposomal + Dichlorphenamide Moderata
- Amphotericin b liposomal + Ifosfamide Moderata
Domande frequenti
Can I take Amphotericin b liposomal with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney, and giving them together may add to the risk of renal impairment. Reduced kidney function can in turn raise tenofovir exposure and worsen tubular toxicity. The liposomal formulation is generally less nephrotoxic than conventional amphotericin B.
How serious is the interaction between Amphotericin b liposomal and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, estimated creatinine clearance, phosphate and electrolytes regularly during combined use. Adjust the tenofovir interval for renal function or choose an alternative if renal function falls.
What other medicines interact with Amphotericin b liposomal?
MediHelp also lists interactions of Amphotericin b liposomal with, for example, Amlodipine-benazepril, Benazepril, Captopril-hydrochlorothiazide. The full list is on the Amphotericin b liposomal page.
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