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Interazioni tra farmaci

Ampicillin-sulbactam + Chloramphenicol

Gravità: Moderata

Ampicillin-sulbactam and Chloramphenicol: moderate interaction.

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Sintesi

Chloramphenicol is bacteriostatic and may reduce the killing activity of beta-lactams in vitro. Clinical significance is uncertain, but it may matter in severe infections such as meningitis.

Cosa significa questa interazione in parole semplici

Ampicillin-sulbactam and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Ampicillin-sulbactam belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.

Livello di evidenza: Low

Perché avviene

Pharmacodynamic antagonism, as inhibition of bacterial protein synthesis may reduce the cell-wall-dependent bactericidal effect of the beta-lactam.

Cosa fare

Avoid combining them in serious infections where bactericidal activity is essential, and choose a single appropriate agent where possible. If used together, monitor clinical and microbiological response.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Ampicillin-sulbactam with Chloramphenicol?

MediHelp rates the interaction as moderate. Ampicillin-sulbactam and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol is bacteriostatic and may reduce the killing activity of beta-lactams in vitro. Clinical significance is uncertain, but it may matter in severe infections such as meningitis.

How serious is the interaction between Ampicillin-sulbactam and Chloramphenicol?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them in serious infections where bactericidal activity is essential, and choose a single appropriate agent where possible. If used together, monitor clinical and microbiological response.

What other medicines interact with Ampicillin-sulbactam?

MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.

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