Interazioni tra farmaci
Apixaban + Ketorolac
Gravità: Controindicata
Apixaban and Ketorolac: contraindicated interaction.
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Sintesi
Ketorolac inhibits platelet function and damages the gastric mucosa, which adds to the bleeding risk of apixaban. Serious gastrointestinal and other hemorrhages may result. Ketorolac labeling contraindicates its use with anticoagulants at therapeutic doses.
Cosa significa questa interazione in parole semplici
Apixaban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apixaban belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Perché avviene
Additive hemostatic impairment: NSAID antiplatelet effect and mucosal injury combined with factor Xa inhibition.
Cosa fare
Avoid the combination and use a non-NSAID analgesic such as paracetamol. If an NSAID is absolutely needed, choose a different agent at the lowest dose with gastroprotection and bleeding monitoring.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Ketorolac
- Aceclofenac + Ketorolac Controindicata
- Acemetacin + Ketorolac Controindicata
- Acetylsalicylic acid + Ketorolac Controindicata
- Argatroban + Ketorolac Controindicata
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Controindicata
- Aspirin rectal + Ketorolac Controindicata
Altre interazioni di Apixaban
- Apixaban + Dabigatran Controindicata
- Apixaban + Defibrotide Controindicata
- Apixaban + Edoxaban Controindicata
- Apixaban + Mifepristone Controindicata
- Abciximab + Apixaban Maggiore
- Acalabrutinib + Apixaban Maggiore
Domande frequenti
Can I take Apixaban with Ketorolac?
MediHelp rates the interaction as contraindicated. Apixaban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac inhibits platelet function and damages the gastric mucosa, which adds to the bleeding risk of apixaban. Serious gastrointestinal and other hemorrhages may result. Ketorolac labeling contraindicates its use with anticoagulants at therapeutic doses.
How serious is the interaction between Apixaban and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-NSAID analgesic such as paracetamol. If an NSAID is absolutely needed, choose a different agent at the lowest dose with gastroprotection and bleeding monitoring.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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