Riferimento farmaci
Netupitant-palonosetron
Netupitant-palonosetron is a medicine in the class gastrointestinal tract. It is used for nausea & vomiting.
- Classe del farmaco: Gastrointestinal Tract
- Indicato per: nausea & vomiting
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Gastrointestinal Tract
- Forme farmaceutiche comuni
- capsula
- Dosaggi comuni
- 300 mg, 0.5 mg
- Interazioni note
- 165 (Controindicata: 2 · Maggiore: 48 · Moderata: 101 · Minore: 14)
- Nomi commerciali
- 5
- Paesi e mercati
- 5
Per cosa si usa
Come agisce
Netupitant: Tachykinin NK1 receptor (substance P) antagonist. Palonosetron: 5-hydroxytryptamine 3 (5-HT3) receptor antagonist; binds to 5-HT3 receptors both in peripheral and central nervous system, with primary effects in GI tract.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Highly emetogenic chemotherapy: 1 capsule (300 mg/0.5 mg) PO ~1 hr before starting chemotherapy OR 1 reconstituted vial (235mg/0.25mg) IV over 30 min starting 30 min before chemotherapy PLUS Dexamethasone 12 mg PO 30 minutes prior to chemotherapy on day 1 and 8 mg PO qDay on days 2-4
Gravidanza e allattamento
- Gravidanza
- Unsafe No human data. Netupitant was teratogenic in rabbits with no safety margin; palonosetron alone showed no harm in animals. EU label: contraindicated in pregnancy; test for pregnancy before use and use contraception until 1 month after. Ondansetron has the most pregnancy data.
- Allattamento
- Unknown Not known if either part passes into milk; netupitant is highly protein bound, so levels are likely low. EU label: do not breastfeed during treatment and for 1 month after. US label: weigh the benefits. LactMed: use with caution; an alternative may be preferred.
Effetti indesiderati segnalati
- Headache
- Fatigue
- Dyspepsia
- Asthenia
Chi deve prestare attenzione
- Netupitant is a CYP3A4 substrate and a moderate inhibitor of CYP3A4.
- Palonosetron is mainly metabolized by CYP2D6 and to a lesser extent by CYP3A4 and CYP1A2
- Strong CYP3A4 inducers (eg, rifampin) can decrease netupitant/palonosetron efficacy by substantially reducing plasma concentrations of the netupitant component; avoid use
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (165)
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
- Encorafenib + Netupitant-palonosetron Major
- Entrectinib + Netupitant-palonosetron Major
- Enzalutamide + Netupitant-palonosetron Major
- Fentanyl + Netupitant-palonosetron Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Netupitant-palonosetron used for?
Netupitant-palonosetron is a medicine in the class gastrointestinal tract. It is used for Nausea & vomiting.
What side effects have been reported with Netupitant-palonosetron?
Headache, Fatigue, Dyspepsia, Asthenia.
Can Netupitant-palonosetron be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No human data. Netupitant was teratogenic in rabbits with no safety margin; palonosetron alone showed no harm in animals. EU label: contraindicated in pregnancy; test for pregnancy before use and use contraception until 1 month after. Ondansetron has the most pregnancy data. Breastfeeding: Unknown. Not known if either part passes into milk; netupitant is highly protein bound, so levels are likely low. EU label: do not breastfeed during treatment and for 1 month after. US label: weigh the benefits. LactMed: use with caution; an alternative may be preferred.
What does Netupitant-palonosetron interact with?
MediHelp lists 165 known interactions for Netupitant-palonosetron. Contraindicated: 2 · Major: 48 · Moderate: 101 · Minor: 14. The most serious include Apomorphine, Flibanserin, Apalutamide.
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