Interazioni tra farmaci
Artemether / lumefantrine + Bosentan
Gravità: Maggiore
Artemether / lumefantrine and Bosentan: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Bosentan is a moderate CYP3A4 inducer and may lower artemether and lumefantrine concentrations, which could cause antimalarial treatment failure. Bosentan itself is a CYP3A4 substrate and levels may be affected as well.
Cosa significa questa interazione in parole semplici
Artemether / lumefantrine and Bosentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
CYP3A4 induction by bosentan increases the metabolism of artemether and lumefantrine.
Cosa fare
Avoid the combination if possible; if malaria treatment is urgent, give full-course therapy and monitor for treatment failure and follow-up parasitemia.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Bosentan
- Bosentan + Cyclosporin Controindicata
- Bosentan + Cyclosporine Controindicata
- Bosentan + Glyburide Controindicata
- Bosentan + Glyburide-metformin Controindicata
- Bosentan + Lonafarnib Controindicata
- Bosentan + Sparsentan Controindicata
Domande frequenti
Can I take Artemether / lumefantrine with Bosentan?
MediHelp rates the interaction as major. Artemether / lumefantrine and Bosentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan is a moderate CYP3A4 inducer and may lower artemether and lumefantrine concentrations, which could cause antimalarial treatment failure. Bosentan itself is a CYP3A4 substrate and levels may be affected as well.
How serious is the interaction between Artemether / lumefantrine and Bosentan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if malaria treatment is urgent, give full-course therapy and monitor for treatment failure and follow-up parasitemia.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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