Interazioni tra farmaci
Bosentan + Cyclosporine
Gravità: Controindicata
Bosentan and Cyclosporine: contraindicated interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Cyclosporine markedly increases bosentan plasma concentrations, while bosentan lowers cyclosporine levels. The rise in bosentan raises the risk of hepatotoxicity, and reduced cyclosporine can compromise immunosuppression and risk graft rejection. Labeling advises against concomitant use.
Cosa significa questa interazione in parole semplici
Bosentan and Cyclosporine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Cyclosporine inhibits OATP-mediated hepatic uptake and CYP3A4 metabolism of bosentan, while bosentan induces CYP3A4, accelerating cyclosporine metabolism.
Cosa fare
Do not co-administer; select an alternative pulmonary hypertension therapy, such as a PDE5 inhibitor, if cyclosporine is required. If bosentan is already in use, discuss alternatives with the transplant and pulmonary hypertension teams before starting cyclosporine.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Riferimenti
Altre interazioni di Bosentan
- Bosentan + Cyclosporin Controindicata
- Bosentan + Glyburide Controindicata
- Bosentan + Glyburide-metformin Controindicata
- Bosentan + Lonafarnib Controindicata
- Bosentan + Sparsentan Controindicata
- Artemether / lumefantrine + Bosentan Maggiore
Domande frequenti
Can I take Bosentan with Cyclosporine?
MediHelp rates the interaction as contraindicated. Bosentan and Cyclosporine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine markedly increases bosentan plasma concentrations, while bosentan lowers cyclosporine levels. The rise in bosentan raises the risk of hepatotoxicity, and reduced cyclosporine can compromise immunosuppression and risk graft rejection. Labeling advises against concomitant use.
How serious is the interaction between Bosentan and Cyclosporine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select an alternative pulmonary hypertension therapy, such as a PDE5 inhibitor, if cyclosporine is required. If bosentan is already in use, discuss alternatives with the transplant and pulmonary hypertension teams before starting cyclosporine.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glyburide, Glyburide-metformin. The full list is on the Bosentan page.
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