Interazioni tra farmaci
Atazanavir + Esomeprazole
Gravità: Maggiore
Atazanavir and Esomeprazole: major interaction.
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Sintesi
Atazanavir needs an acidic stomach to dissolve, so esomeprazole can markedly reduce its levels. This may lead to virologic failure and development of resistance.
Cosa significa questa interazione in parole semplici
Atazanavir and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Esomeprazole belongs to Gastrointestinal Tract.
Perché avviene
Higher gastric pH decreases atazanavir solubility and absorption.
Cosa fare
Avoid PPIs in treatment-experienced patients. In treatment-naive patients on ritonavir-boosted atazanavir, keep the PPI dose to an omeprazole 20 mg equivalent, give it about 12 hours before atazanavir, and monitor viral load.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Esomeprazole
- Esomeprazole + Mavacamten Controindicata
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- Acalabrutinib + Esomeprazole Maggiore
- Citalopram + Esomeprazole Maggiore
- Clopidogrel + Esomeprazole Maggiore
- Dacomitinib + Esomeprazole Maggiore
Altre interazioni di Atazanavir
- Alfuzosin + Atazanavir Controindicata
- Atazanavir + Avanafil Controindicata
- Atazanavir + Dronedarone Controindicata
- Atazanavir + Eletriptan Controindicata
- Atazanavir + Eplerenone Controindicata
- Atazanavir + Ergotamine Controindicata
Domande frequenti
Can I take Atazanavir with Esomeprazole?
MediHelp rates the interaction as major. Atazanavir and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir needs an acidic stomach to dissolve, so esomeprazole can markedly reduce its levels. This may lead to virologic failure and development of resistance.
How serious is the interaction between Atazanavir and Esomeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs in treatment-experienced patients. In treatment-naive patients on ritonavir-boosted atazanavir, keep the PPI dose to an omeprazole 20 mg equivalent, give it about 12 hours before atazanavir, and monitor viral load.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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