Interazioni tra farmaci
Atazanavir + Tofacitinib
Gravità: Maggiore
Atazanavir and Tofacitinib: major interaction.
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Sintesi
Atazanavir inhibits CYP3A4 and raises tofacitinib exposure, increasing the risk of dose-related adverse effects such as infection, cytopenias and lipid elevations. Labeling recommends reducing the tofacitinib dose with strong CYP3A4 inhibitors.
Cosa significa questa interazione in parole semplici
Atazanavir and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Tofacitinib belongs to Musculoskeletal.
Perché avviene
Strong CYP3A4 inhibition by ritonavir-boosted or unboosted atazanavir reduces tofacitinib clearance.
Cosa fare
Reduce tofacitinib to the labeled lower dose, for example once daily when the usual dose is twice daily. Monitor for infection and cytopenias.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Tofacitinib
- Baricitinib + Tofacitinib Controindicata
- Cladribine + Tofacitinib Controindicata
- Tofacitinib + Upadacitinib Controindicata
- Abatacept + Tofacitinib Maggiore
- Anti-thymocyte + Tofacitinib Maggiore
- Antithymocyte globulin equine + Tofacitinib Maggiore
Altre interazioni di Atazanavir
- Alfuzosin + Atazanavir Controindicata
- Atazanavir + Avanafil Controindicata
- Atazanavir + Dronedarone Controindicata
- Atazanavir + Eletriptan Controindicata
- Atazanavir + Eplerenone Controindicata
- Atazanavir + Ergotamine Controindicata
Domande frequenti
Can I take Atazanavir with Tofacitinib?
MediHelp rates the interaction as major. Atazanavir and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir inhibits CYP3A4 and raises tofacitinib exposure, increasing the risk of dose-related adverse effects such as infection, cytopenias and lipid elevations. Labeling recommends reducing the tofacitinib dose with strong CYP3A4 inhibitors.
How serious is the interaction between Atazanavir and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce tofacitinib to the labeled lower dose, for example once daily when the usual dose is twice daily. Monitor for infection and cytopenias.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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