Interazioni tra farmaci
Tofacitinib + Upadacitinib
Gravità: Controindicata
Tofacitinib and Upadacitinib: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Two JAK inhibitors together duplicate pharmacology and give additive immunosuppression, increasing the risk of serious infection, cytopenias and other class adverse effects. There is no evidence of benefit from combining them.
Cosa significa questa interazione in parole semplici
Tofacitinib and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Tofacitinib belongs to Musculoskeletal; Upadacitinib belongs to Musculoskeletal.
Perché avviene
Duplicate JAK inhibition leads to additive immunosuppression.
Cosa fare
Do not use together; use one JAK inhibitor only, and stop the first before starting the other.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Tofacitinib
- Baricitinib + Tofacitinib Controindicata
- Cladribine + Tofacitinib Controindicata
- Abatacept + Tofacitinib Maggiore
- Anti-thymocyte + Tofacitinib Maggiore
- Antithymocyte globulin equine + Tofacitinib Maggiore
- Antithymocyte globulin rabbit + Tofacitinib Maggiore
Altre interazioni di Upadacitinib
- Abrocitinib + Upadacitinib Controindicata
- Adenovirus types 4 and 7 live + Upadacitinib Controindicata
- Baricitinib + Upadacitinib Controindicata
- Bcg vaccine live + Upadacitinib Controindicata
- Cyclosporine + Upadacitinib Controindicata
- Dengue vaccine + Upadacitinib Controindicata
Domande frequenti
Can I take Tofacitinib with Upadacitinib?
MediHelp rates the interaction as contraindicated. Tofacitinib and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Two JAK inhibitors together duplicate pharmacology and give additive immunosuppression, increasing the risk of serious infection, cytopenias and other class adverse effects. There is no evidence of benefit from combining them.
How serious is the interaction between Tofacitinib and Upadacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; use one JAK inhibitor only, and stop the first before starting the other.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Abatacept. The full list is on the Tofacitinib page.
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