Interazioni tra farmaci
Atidarsagene autotemcel + Raltegravir
Gravità: Maggiore
Atidarsagene autotemcel and Raltegravir: major interaction.
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Sintesi
Antiretroviral drugs can interfere with the manufacture of this lentiviral gene therapy by inhibiting transduction of mobilized cells. Raltegravir, an integrase inhibitor, may reduce the efficiency of vector integration.
Cosa significa questa interazione in parole semplici
Atidarsagene autotemcel and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Raltegravir belongs to Anti Virals.
Perché avviene
Antiretrovirals inhibit lentiviral vector transduction of harvested stem cells during manufacturing.
Cosa fare
Stop raltegravir at least one month before mobilization, or longer to cover drug elimination, and keep it off through apheresis. Arrange alternative HIV management with the treating team.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Raltegravir
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir Controindicata
- Aluminum hydroxide / magnesium carbonate + Raltegravir Maggiore
- Aluminum hydroxide / magnesium trisilicate + Raltegravir Maggiore
- Aluminum hydroxide + Raltegravir Maggiore
- Betibeglogene autotemcel + Raltegravir Maggiore
- Cabotegravir + Raltegravir Maggiore
Altre interazioni di Atidarsagene autotemcel
Domande frequenti
Can I take Atidarsagene autotemcel with Raltegravir?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretroviral drugs can interfere with the manufacture of this lentiviral gene therapy by inhibiting transduction of mobilized cells. Raltegravir, an integrase inhibitor, may reduce the efficiency of vector integration.
How serious is the interaction between Atidarsagene autotemcel and Raltegravir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop raltegravir at least one month before mobilization, or longer to cover drug elimination, and keep it off through apheresis. Arrange alternative HIV management with the treating team.
What other medicines interact with Raltegravir?
MediHelp also lists interactions of Raltegravir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Raltegravir page.
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