Interazioni tra farmaci
Bcg vaccine live + Lomustine
Gravità: Controindicata
Bcg vaccine live and Lomustine: contraindicated interaction.
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Sintesi
Lomustine suppresses bone marrow and immune function, so live BCG may cause disseminated BCG infection. Vaccine efficacy is also reduced.
Cosa significa questa interazione in parole semplici
Bcg vaccine live and Lomustine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Cytotoxic immunosuppression impairs control of live vaccine bacteria and reduces the immune response.
Cosa fare
Avoid BCG vaccination during lomustine therapy and until immune recovery, generally at least 3 months after stopping. Seek specialist advice if exposure risk is high.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Lomustine
- Adenovirus types 4 and 7 live + Lomustine Controindicata
- Influenza virus vaccine quadrivalent intranasal + Lomustine Controindicata
- Lomustine + Measles mumps and rubella vaccine Controindicata
- Lomustine + Measles mumps and rubella vaccine live Controindicata
- Lomustine + Measles mumps rubella and varicella vaccine live Controindicata
- Lomustine + Measles vaccine Controindicata
Domande frequenti
Can I take Bcg vaccine live with Lomustine?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Lomustine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lomustine suppresses bone marrow and immune function, so live BCG may cause disseminated BCG infection. Vaccine efficacy is also reduced.
How serious is the interaction between Bcg vaccine live and Lomustine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid BCG vaccination during lomustine therapy and until immune recovery, generally at least 3 months after stopping. Seek specialist advice if exposure risk is high.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Lomustine page.
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