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Interazioni tra farmaci

Lomustine + Measles mumps rubella and varicella vaccine live

Gravità: Controindicata

Lomustine and Measles mumps rubella and varicella vaccine live: contraindicated interaction.

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Sintesi

The combined live MMRV vaccine carries a risk of disseminated vaccine-strain infection in patients immunosuppressed by lomustine, and immunogenicity is reduced.

Cosa significa questa interazione in parole semplici

Lomustine and Measles mumps rubella and varicella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Livello di evidenza: High

Perché avviene

Cytotoxic immunosuppression impairs control of live vaccine virus replication and reduces the immune response.

Cosa fare

Avoid during lomustine therapy and until immune recovery, generally at least 3 months after treatment. Revaccinate once immune function is restored.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Lomustine with Measles mumps rubella and varicella vaccine live?

MediHelp rates the interaction as contraindicated. Lomustine and Measles mumps rubella and varicella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The combined live MMRV vaccine carries a risk of disseminated vaccine-strain infection in patients immunosuppressed by lomustine, and immunogenicity is reduced.

How serious is the interaction between Lomustine and Measles mumps rubella and varicella vaccine live?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during lomustine therapy and until immune recovery, generally at least 3 months after treatment. Revaccinate once immune function is restored.

What other medicines interact with Lomustine?

MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.

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