Interazioni tra farmaci
Benazepril + Hydrochlorothiazide-irbesartan
Gravità: Maggiore
Benazepril and Hydrochlorothiazide-irbesartan: major interaction.
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Sintesi
Combining an angiotensin receptor blocker with an ACE inhibitor produces dual renin-angiotensin system blockade. This raises the risk of symptomatic hypotension, hyperkalemia and acute kidney injury without a meaningful gain in cardiovascular outcomes.
Cosa significa questa interazione in parole semplici
Benazepril and Hydrochlorothiazide-irbesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Benazepril belongs to Cardiovascular; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Perché avviene
Additive pharmacodynamic suppression of angiotensin II activity at two points of the renin-angiotensin system reduces glomerular filtration pressure and aldosterone-mediated potassium excretion.
Cosa fare
Avoid the combination in routine practice and choose a single renin-angiotensin agent. If it is used for a specific indication, monitor blood pressure, serum potassium and creatinine closely.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Controindicata
- Dofetilide + Hydrochlorothiazide-irbesartan Controindicata
- Hydrochlorothiazide-irbesartan + Sparsentan Controindicata
- Aldesleukin + Hydrochlorothiazide-irbesartan Maggiore
- Amifostine + Hydrochlorothiazide-irbesartan Maggiore
- Amiloride + Hydrochlorothiazide-irbesartan Maggiore
Altre interazioni di Benazepril
- Aliskiren + Benazepril Controindicata
- Benazepril + Sacubitril / valsartan Controindicata
- Benazepril + Sacubitril-valsartan Controindicata
- Amifostine + Benazepril Maggiore
- Amiloride + Benazepril Maggiore
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Maggiore
Domande frequenti
Can I take Benazepril with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as major. Benazepril and Hydrochlorothiazide-irbesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an angiotensin receptor blocker with an ACE inhibitor produces dual renin-angiotensin system blockade. This raises the risk of symptomatic hypotension, hyperkalemia and acute kidney injury without a meaningful gain in cardiovascular outcomes.
How serious is the interaction between Benazepril and Hydrochlorothiazide-irbesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in routine practice and choose a single renin-angiotensin agent. If it is used for a specific indication, monitor blood pressure, serum potassium and creatinine closely.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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