Interazioni tra farmaci
Hydrochlorothiazide-irbesartan + Sparsentan
Gravità: Controindicata
Hydrochlorothiazide-irbesartan and Sparsentan: contraindicated interaction.
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Sintesi
Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding an ARB duplicates angiotensin blockade. This increases the risk of hypotension, hyperkalemia and acute kidney injury.
Cosa significa questa interazione in parole semplici
Hydrochlorothiazide-irbesartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
Perché avviene
Additive angiotensin II type 1 receptor blockade, since sparsentan itself has ARB activity.
Cosa fare
Do not use together; stop the ARB before starting sparsentan. Monitor blood pressure, potassium and renal function when changing therapy.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Controindicata
- Dofetilide + Hydrochlorothiazide-irbesartan Controindicata
- Aldesleukin + Hydrochlorothiazide-irbesartan Maggiore
- Amifostine + Hydrochlorothiazide-irbesartan Maggiore
- Amiloride + Hydrochlorothiazide-irbesartan Maggiore
- Benazepril + Hydrochlorothiazide-irbesartan Maggiore
Altre interazioni di Sparsentan
- Aliskiren + Sparsentan Controindicata
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Controindicata
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Controindicata
- Amlodipine-olmesartan + Sparsentan Controindicata
- Amlodipine-valsartan + Sparsentan Controindicata
- Azilsartan-chlorthalidone + Sparsentan Controindicata
Domande frequenti
Can I take Hydrochlorothiazide-irbesartan with Sparsentan?
MediHelp rates the interaction as contraindicated. Hydrochlorothiazide-irbesartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding an ARB duplicates angiotensin blockade. This increases the risk of hypotension, hyperkalemia and acute kidney injury.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; stop the ARB before starting sparsentan. Monitor blood pressure, potassium and renal function when changing therapy.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Aldesleukin. The full list is on the Hydrochlorothiazide-irbesartan page.
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