Interazioni tra farmaci
Benzphetamine + Selegiline
Gravità: Controindicata
Benzphetamine and Selegiline: contraindicated interaction.
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Sintesi
Selegiline, particularly in the transdermal form that provides non-selective MAO inhibition, can greatly amplify the sympathomimetic effects of benzphetamine. This may precipitate a hypertensive crisis with severe headache, arrhythmia or intracranial haemorrhage.
Cosa significa questa interazione in parole semplici
Benzphetamine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
MAO inhibition allows accumulation of norepinephrine and other monoamines, and benzphetamine adds indirect sympathomimetic release, producing additive pressor effects.
Cosa fare
Do not co-administer; benzphetamine labeling contraindicates use during or within 14 days of an MAO inhibitor. Choose a non-sympathomimetic weight management approach.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Selegiline
- Amitriptyline + Selegiline Controindicata
- Amoxapine + Selegiline Controindicata
- Atomoxetine + Selegiline Controindicata
- Brimonidine + Selegiline Controindicata
- Buprenorphine long-acting + Selegiline Controindicata
- Bupropion-naltrexone + Selegiline Controindicata
Domande frequenti
Can I take Benzphetamine with Selegiline?
MediHelp rates the interaction as contraindicated. Benzphetamine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline, particularly in the transdermal form that provides non-selective MAO inhibition, can greatly amplify the sympathomimetic effects of benzphetamine. This may precipitate a hypertensive crisis with severe headache, arrhythmia or intracranial haemorrhage.
How serious is the interaction between Benzphetamine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; benzphetamine labeling contraindicates use during or within 14 days of an MAO inhibitor. Choose a non-sympathomimetic weight management approach.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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