Interazioni tra farmaci
Buprenorphine long-acting + Selegiline
Gravità: Controindicata
Buprenorphine long-acting and Selegiline: contraindicated interaction.
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Sintesi
Concurrent use may cause serotonin syndrome or opioid toxicity such as respiratory depression and coma. Long-acting buprenorphine cannot be quickly withdrawn, which makes any reaction harder to manage.
Cosa significa questa interazione in parole semplici
Buprenorphine long-acting and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
MAO inhibition combined with serotonergic opioid activity increases serotonin, and MAO inhibitors may also potentiate opioid effects.
Cosa fare
Do not use long-acting buprenorphine in patients taking an MAO inhibitor or within 14 days of stopping one. Choose a non-serotonergic alternative.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Domande frequenti
Can I take Buprenorphine long-acting with Selegiline?
MediHelp rates the interaction as contraindicated. Buprenorphine long-acting and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Concurrent use may cause serotonin syndrome or opioid toxicity such as respiratory depression and coma. Long-acting buprenorphine cannot be quickly withdrawn, which makes any reaction harder to manage.
How serious is the interaction between Buprenorphine long-acting and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use long-acting buprenorphine in patients taking an MAO inhibitor or within 14 days of stopping one. Choose a non-serotonergic alternative.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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