Interazioni tra farmaci
Bethanechol + Umeclidinium
Gravità: Moderata
Bethanechol and Umeclidinium: moderate interaction.
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Sintesi
Bethanechol is a muscarinic agonist and umeclidinium is a muscarinic antagonist, so each can oppose the effect of the other. The practical result is reduced efficacy of bethanechol, for example in urinary retention, and the size of the effect with inhaled umeclidinium is uncertain.
Cosa significa questa interazione in parole semplici
Bethanechol and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bethanechol belongs to Gastrointestinal Tract; Umeclidinium belongs to Respiratory.
Perché avviene
Pharmacodynamic antagonism at muscarinic receptors.
Cosa fare
Monitor for loss of bethanechol effect, such as persistent urinary retention, and for worsening of airway symptoms; adjust therapy if the response is inadequate.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Umeclidinium
- Tiotropium + Umeclidinium Maggiore
- Aclidinium + Umeclidinium Moderata
- Atropine iv / + Umeclidinium Moderata
- Atropine + Umeclidinium Moderata
- Belladonna alkaloids + Umeclidinium Moderata
- Dicyclomine + Umeclidinium Moderata
Altre interazioni di Bethanechol
- Bethanechol + Darifenacin Maggiore
- Bethanechol + Fesoterodine Maggiore
- Bethanechol + Oxybutynin Maggiore
- Bethanechol + Physostigmine Maggiore
- Amifampridine + Bethanechol Moderata
- Amitriptyline + Bethanechol Moderata
Domande frequenti
Can I take Bethanechol with Umeclidinium?
MediHelp rates the interaction as moderate. Bethanechol and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bethanechol is a muscarinic agonist and umeclidinium is a muscarinic antagonist, so each can oppose the effect of the other. The practical result is reduced efficacy of bethanechol, for example in urinary retention, and the size of the effect with inhaled umeclidinium is uncertain.
How serious is the interaction between Bethanechol and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of bethanechol effect, such as persistent urinary retention, and for worsening of airway symptoms; adjust therapy if the response is inadequate.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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