Drug interactions
Bethanechol + Umeclidinium
Severity: Moderate
Bethanechol and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bethanechol is a muscarinic agonist and umeclidinium is a muscarinic antagonist, so each can oppose the effect of the other. The practical result is reduced efficacy of bethanechol, for example in urinary retention, and the size of the effect with inhaled umeclidinium is uncertain.
What this interaction means in plain words
Bethanechol and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bethanechol belongs to Gastrointestinal Tract; Umeclidinium belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for loss of bethanechol effect, such as persistent urinary retention, and for worsening of airway symptoms; adjust therapy if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Dicyclomine + Umeclidinium Moderate
Other interactions of Bethanechol
- Bethanechol + Darifenacin Major
- Bethanechol + Fesoterodine Major
- Bethanechol + Oxybutynin Major
- Bethanechol + Physostigmine Major
- Amifampridine + Bethanechol Moderate
- Amitriptyline + Bethanechol Moderate
Frequently asked questions
Can I take Bethanechol with Umeclidinium?
MediHelp rates the interaction as moderate. Bethanechol and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bethanechol is a muscarinic agonist and umeclidinium is a muscarinic antagonist, so each can oppose the effect of the other. The practical result is reduced efficacy of bethanechol, for example in urinary retention, and the size of the effect with inhaled umeclidinium is uncertain.
How serious is the interaction between Bethanechol and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of bethanechol effect, such as persistent urinary retention, and for worsening of airway symptoms; adjust therapy if the response is inadequate.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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