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Interazioni tra farmaci

Bleomycin + Brentuximab

Gravità: Controindicata

Bleomycin and Brentuximab: contraindicated interaction.

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Sintesi

Bleomycin causes dose-related pulmonary toxicity, and adding brentuximab vedotin has led to excess pulmonary injury in Hodgkin lymphoma regimens. Cough, dyspnoea and fatal respiratory failure are recorded.

Cosa significa questa interazione in parole semplici

Bleomycin and Brentuximab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Bleomycin belongs to Oncology; Brentuximab belongs to Oncology.

Livello di evidenza: High

Perché avviene

Additive pulmonary toxicity

Cosa fare

Do not use bleomycin together with brentuximab vedotin; use a bleomycin-free regimen (for example AVD with brentuximab) and report new respiratory symptoms promptly.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Bleomycin with Brentuximab?

MediHelp rates the interaction as contraindicated. Bleomycin and Brentuximab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Bleomycin causes dose-related pulmonary toxicity, and adding brentuximab vedotin has led to excess pulmonary injury in Hodgkin lymphoma regimens. Cough, dyspnoea and fatal respiratory failure are recorded.

How serious is the interaction between Bleomycin and Brentuximab?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use bleomycin together with brentuximab vedotin; use a bleomycin-free regimen (for example AVD with brentuximab) and report new respiratory symptoms promptly.

What other medicines interact with Brentuximab?

MediHelp also lists interactions of Brentuximab with, for example, Dengue vaccine, Etrasimod, Idelalisib. The full list is on the Brentuximab page.

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