Interazioni tra farmaci
Brentuximab + Idelalisib
Gravità: Maggiore
Brentuximab and Idelalisib: major interaction.
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Sintesi
Idelalisib is a strong CYP3A inhibitor, and MMAE from brentuximab vedotin is a CYP3A4 substrate. Strong CYP3A4 inhibitors raise MMAE exposure, which may increase neutropenia and other toxicities. Idelalisib itself also carries infection and neutropenia risk.
Cosa significa questa interazione in parole semplici
Brentuximab and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brentuximab belongs to Oncology; Idelalisib belongs to Oncology.
Perché avviene
Strong CYP3A inhibition by idelalisib reduces MMAE metabolism and increases exposure.
Cosa fare
Monitor closely for neutropenia, infection and neuropathy, and consider an alternative to idelalisib. Hold or reduce brentuximab if toxicity occurs.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Brentuximab
- Bleomycin + Brentuximab Controindicata
- Brentuximab + Dengue vaccine Maggiore
- Brentuximab + Etrasimod Maggiore
- Brentuximab + Levoketoconazole Maggiore
- Brentuximab + Nefazodone Maggiore
- Brentuximab + Ritonavir Maggiore
Altre interazioni di Idelalisib
- Alfuzosin + Idelalisib Controindicata
- Cisapride + Idelalisib Controindicata
- Dihydroergotamine + Idelalisib Controindicata
- Dronedarone + Idelalisib Controindicata
- Eletriptan + Idelalisib Controindicata
- Eplerenone + Idelalisib Controindicata
Domande frequenti
Can I take Brentuximab with Idelalisib?
MediHelp rates the interaction as major. Brentuximab and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor, and MMAE from brentuximab vedotin is a CYP3A4 substrate. Strong CYP3A4 inhibitors raise MMAE exposure, which may increase neutropenia and other toxicities. Idelalisib itself also carries infection and neutropenia risk.
How serious is the interaction between Brentuximab and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia, infection and neuropathy, and consider an alternative to idelalisib. Hold or reduce brentuximab if toxicity occurs.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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