Interazioni tra farmaci
Blinatumomab + Sirolimus
Gravità: Moderata
Blinatumomab and Sirolimus: moderate interaction.
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Sintesi
Blinatumomab causes transient cytokine release that can suppress CYP450 enzymes, mainly in the first days of each cycle. This may transiently raise sirolimus concentrations and cause toxicity.
Cosa significa questa interazione in parole semplici
Blinatumomab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Sirolimus belongs to Miscellaneous.
Perché avviene
Cytokine-mediated transient suppression of CYP3A4 reducing sirolimus metabolism.
Cosa fare
Monitor sirolimus trough levels and toxicity during the first days of each blinatumomab cycle. Adjust the sirolimus dose as needed.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Controindicata
- Bcg vaccine live + Sirolimus Controindicata
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Controindicata
- Ketoconazole + Sirolimus Controindicata
- Levoketoconazole + Sirolimus Controindicata
- Measles mumps and rubella vaccine live + Sirolimus Controindicata
Altre interazioni di Blinatumomab
- Blinatumomab + Carbamazepine Moderata
- Blinatumomab + Cyclosporin Moderata
- Blinatumomab + Ethosuximide Moderata
- Blinatumomab + Phenytoin Moderata
- Blinatumomab + Quinidine Moderata
- Blinatumomab + Quinine Moderata
Domande frequenti
Can I take Blinatumomab with Sirolimus?
MediHelp rates the interaction as moderate. Blinatumomab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes transient cytokine release that can suppress CYP450 enzymes, mainly in the first days of each cycle. This may transiently raise sirolimus concentrations and cause toxicity.
How serious is the interaction between Blinatumomab and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels and toxicity during the first days of each blinatumomab cycle. Adjust the sirolimus dose as needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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