Interazioni tra farmaci
Blinatumomab + Cyclosporin
Gravità: Moderata
Blinatumomab and Cyclosporin: moderate interaction.
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Sintesi
Blinatumomab causes a transient cytokine release at treatment initiation and after dose re-starts, which can temporarily suppress CYP450 activity. Cyclosporine is a narrow therapeutic index CYP3A4 substrate, so its blood concentrations may rise and increase the risk of nephrotoxicity and neurotoxicity.
Cosa significa questa interazione in parole semplici
Blinatumomab and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Perché avviene
Cytokine release (e.g., IL-6) transiently downregulates CYP450 enzymes, reducing cyclosporine metabolism.
Cosa fare
Monitor cyclosporine trough concentrations and renal function closely during the first days of the first cycle and after re-initiation of blinatumomab. Reduce the cyclosporine dose according to levels and clinical signs of toxicity.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Controindicata
- Aliskiren + Cyclosporin Controindicata
- Bcg vaccine live + Cyclosporin Controindicata
- Bosentan + Cyclosporin Controindicata
- Cidofovir + Cyclosporin Controindicata
- Cyclosporin + Dengue vaccine Controindicata
Altre interazioni di Blinatumomab
- Blinatumomab + Carbamazepine Moderata
- Blinatumomab + Ethosuximide Moderata
- Blinatumomab + Phenytoin Moderata
- Blinatumomab + Quinidine Moderata
- Blinatumomab + Quinine Moderata
- Blinatumomab + Siponimod Moderata
Domande frequenti
Can I take Blinatumomab with Cyclosporin?
MediHelp rates the interaction as moderate. Blinatumomab and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes a transient cytokine release at treatment initiation and after dose re-starts, which can temporarily suppress CYP450 activity. Cyclosporine is a narrow therapeutic index CYP3A4 substrate, so its blood concentrations may rise and increase the risk of nephrotoxicity and neurotoxicity.
How serious is the interaction between Blinatumomab and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations and renal function closely during the first days of the first cycle and after re-initiation of blinatumomab. Reduce the cyclosporine dose according to levels and clinical signs of toxicity.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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