Interazioni tra farmaci
Blinatumomab + Tacrolimus
Gravità: Moderata
Blinatumomab and Tacrolimus: moderate interaction.
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Sintesi
Cytokine release at the start of blinatumomab treatment can temporarily suppress CYP450 enzymes, which may raise tacrolimus concentrations. Elevated tacrolimus levels increase the risk of nephrotoxicity and neurotoxicity.
Cosa significa questa interazione in parole semplici
Blinatumomab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Perché avviene
Transient cytokine-mediated suppression of CYP3A4 reduces tacrolimus metabolism.
Cosa fare
Monitor tacrolimus trough levels and renal function closely during the first days of each blinatumomab cycle. Reduce the tacrolimus dose as needed.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Controindicata
- Bcg vaccine live + Tacrolimus Controindicata
- Cidofovir + Tacrolimus Controindicata
- Cyclosporin + Tacrolimus Controindicata
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Controindicata
- Measles mumps and rubella vaccine live + Tacrolimus Controindicata
Altre interazioni di Blinatumomab
- Blinatumomab + Carbamazepine Moderata
- Blinatumomab + Cyclosporin Moderata
- Blinatumomab + Ethosuximide Moderata
- Blinatumomab + Phenytoin Moderata
- Blinatumomab + Quinidine Moderata
- Blinatumomab + Quinine Moderata
Domande frequenti
Can I take Blinatumomab with Tacrolimus?
MediHelp rates the interaction as moderate. Blinatumomab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release at the start of blinatumomab treatment can temporarily suppress CYP450 enzymes, which may raise tacrolimus concentrations. Elevated tacrolimus levels increase the risk of nephrotoxicity and neurotoxicity.
How serious is the interaction between Blinatumomab and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function closely during the first days of each blinatumomab cycle. Reduce the tacrolimus dose as needed.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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