Interazioni tra farmaci
Buprenorphine + Calcium / magnesium / potassium / sodium oxybates
Gravità: Controindicata
Buprenorphine and Calcium / magnesium / potassium / sodium oxybates: contraindicated interaction.
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Sintesi
Oxybates are potent CNS depressants, and combining them with opioids can cause profound sedation, respiratory depression, coma and death. Labeling for oxybates restricts co-use with other CNS depressants.
Cosa significa questa interazione in parole semplici
Buprenorphine and Calcium / magnesium / potassium / sodium oxybates are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Additive CNS and respiratory depression via GABA-B/GHB receptor agonism and mu-opioid agonism.
Cosa fare
Avoid the combination. If an opioid is unavoidable, consider interrupting oxybate treatment, and monitor closely for respiratory depression.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Buprenorphine
- Alvimopan + Buprenorphine Controindicata
- Buprenorphine + Olanzapine / samidorphan Controindicata
- Buprenorphine + Phenelzine Controindicata
- Buprenorphine + Pimozide Controindicata
- Buprenorphine + Thioridazine Controindicata
- Buprenorphine + Tranylcypromine Controindicata
Domande frequenti
Can I take Buprenorphine with Calcium / magnesium / potassium / sodium oxybates?
MediHelp rates the interaction as contraindicated. Buprenorphine and Calcium / magnesium / potassium / sodium oxybates are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybates are potent CNS depressants, and combining them with opioids can cause profound sedation, respiratory depression, coma and death. Labeling for oxybates restricts co-use with other CNS depressants.
How serious is the interaction between Buprenorphine and Calcium / magnesium / potassium / sodium oxybates?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If an opioid is unavoidable, consider interrupting oxybate treatment, and monitor closely for respiratory depression.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Olanzapine / samidorphan, Phenelzine. The full list is on the Buprenorphine page.
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