Interazioni tra farmaci
Buprenorphine + Pimozide
Gravità: Controindicata
Buprenorphine and Pimozide: contraindicated interaction.
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Sintesi
Buprenorphine can lengthen the QT interval, particularly at higher doses or in the transdermal form, and pimozide is a strongly QT-prolonging antipsychotic. The combination increases the risk of torsades de pointes.
Cosa significa questa interazione in parole semplici
Buprenorphine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Buprenorphine belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Perché avviene
Additive QTc prolongation
Cosa fare
Avoid; use a non-QT-prolonging alternative to the antipsychotic or analgesic and monitor ECG if unavoidable.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Buprenorphine
- Alvimopan + Buprenorphine Controindicata
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Controindicata
- Buprenorphine + Olanzapine / samidorphan Controindicata
- Buprenorphine + Phenelzine Controindicata
- Buprenorphine + Thioridazine Controindicata
- Buprenorphine + Tranylcypromine Controindicata
Altre interazioni di Pimozide
- Adagrasib + Pimozide Controindicata
- Amiodarone + Pimozide Controindicata
- Amisulpride + Pimozide Controindicata
- Amitriptyline + Pimozide Controindicata
- Amoxapine + Pimozide Controindicata
- Anagrelide + Pimozide Controindicata
Domande frequenti
Can I take Buprenorphine with Pimozide?
MediHelp rates the interaction as contraindicated. Buprenorphine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Buprenorphine can lengthen the QT interval, particularly at higher doses or in the transdermal form, and pimozide is a strongly QT-prolonging antipsychotic. The combination increases the risk of torsades de pointes.
How serious is the interaction between Buprenorphine and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; use a non-QT-prolonging alternative to the antipsychotic or analgesic and monitor ECG if unavoidable.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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