Interazioni tra farmaci
Buprenorphine + Phenelzine
Gravità: Controindicata
Buprenorphine and Phenelzine: contraindicated interaction.
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Sintesi
Opioids combined with MAO inhibitors such as phenelzine have caused serotonin syndrome, severe hypotension or hypertension, hyperpyrexia and CNS depression. Buprenorphine labeling advises against use during or shortly after MAOI therapy.
Cosa significa questa interazione in parole semplici
Buprenorphine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Buprenorphine belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.
Perché avviene
MAO inhibition may potentiate serotonergic and CNS effects of opioids; precise mechanism for buprenorphine is not fully defined.
Cosa fare
Do not use buprenorphine with phenelzine or within 14 days after stopping an MAOI. Use a non-opioid analgesic or an alternative.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Buprenorphine
- Alvimopan + Buprenorphine Controindicata
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Controindicata
- Buprenorphine + Olanzapine / samidorphan Controindicata
- Buprenorphine + Pimozide Controindicata
- Buprenorphine + Thioridazine Controindicata
- Buprenorphine + Tranylcypromine Controindicata
Altre interazioni di Phenelzine
- 5-HTP + Phenelzine Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amoxapine + Phenelzine Controindicata
- Atomoxetine + Phenelzine Controindicata
- Benzphetamine + Phenelzine Controindicata
- Brimonidine + Phenelzine Controindicata
Domande frequenti
Can I take Buprenorphine with Phenelzine?
MediHelp rates the interaction as contraindicated. Buprenorphine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids combined with MAO inhibitors such as phenelzine have caused serotonin syndrome, severe hypotension or hypertension, hyperpyrexia and CNS depression. Buprenorphine labeling advises against use during or shortly after MAOI therapy.
How serious is the interaction between Buprenorphine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use buprenorphine with phenelzine or within 14 days after stopping an MAOI. Use a non-opioid analgesic or an alternative.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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