Interazioni tra farmaci
Buspirone + Procarbazine
Gravità: Controindicata
Buspirone and Procarbazine: contraindicated interaction.
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Sintesi
Procarbazine (a cytotoxic drug with weak MAO-inhibiting activity) added to buspirone, a serotonin 5-HT1A partial agonist, has been associated with raised blood pressure and with serotonergic toxicity. Buspirone labelling advises against concurrent MAOI use.
Cosa significa questa interazione in parole semplici
Buspirone and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Buspirone belongs to Central Nervous System; Procarbazine belongs to Oncology.
Perché avviene
Combined serotonergic activity with MAO inhibition; possible pressor reaction
Cosa fare
Avoid the combination. Wait at least 14 days after stopping procarbazine before starting the other drug.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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- Evidence detail
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Altre interazioni di Buspirone
- Buspirone + Isocarboxazid Controindicata
- Buspirone + Linezolid Controindicata
- Buspirone + Phenelzine Controindicata
- Buspirone + Selegiline Controindicata
- Buspirone + Selegiline transdermal Controindicata
- Buspirone + Tranylcypromine Controindicata
Altre interazioni di Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Controindicata
- Amitriptyline + Procarbazine Controindicata
- Amoxapine + Procarbazine Controindicata
- Atomoxetine + Procarbazine Controindicata
- Bcg vaccine live + Procarbazine Controindicata
- Brimonidine + Procarbazine Controindicata
Domande frequenti
Can I take Buspirone with Procarbazine?
MediHelp rates the interaction as contraindicated. Buspirone and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine (a cytotoxic drug with weak MAO-inhibiting activity) added to buspirone, a serotonin 5-HT1A partial agonist, has been associated with raised blood pressure and with serotonergic toxicity. Buspirone labelling advises against concurrent MAOI use.
How serious is the interaction between Buspirone and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Wait at least 14 days after stopping procarbazine before starting the other drug.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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