Interazioni tra farmaci
Buspirone + Selegiline
Gravità: Controindicata
Buspirone and Selegiline: contraindicated interaction.
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Sintesi
Selegiline (an MAO-B inhibitor that loses selectivity at higher or transdermal doses) added to buspirone, a serotonin 5-HT1A partial agonist, has been associated with raised blood pressure and with serotonergic toxicity. Buspirone labelling advises against concurrent MAOI use.
Cosa significa questa interazione in parole semplici
Buspirone and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Buspirone belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Perché avviene
Combined serotonergic activity with MAO inhibition; possible pressor reaction
Cosa fare
Avoid the combination. Wait at least 14 days after stopping selegiline before starting the other drug.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Altre interazioni di Selegiline
- Amitriptyline + Selegiline Controindicata
- Amoxapine + Selegiline Controindicata
- Atomoxetine + Selegiline Controindicata
- Benzphetamine + Selegiline Controindicata
- Brimonidine + Selegiline Controindicata
- Buprenorphine long-acting + Selegiline Controindicata
Altre interazioni di Buspirone
- Buspirone + Isocarboxazid Controindicata
- Buspirone + Linezolid Controindicata
- Buspirone + Phenelzine Controindicata
- Buspirone + Procarbazine Controindicata
- Buspirone + Selegiline transdermal Controindicata
- Buspirone + Tranylcypromine Controindicata
Domande frequenti
Can I take Buspirone with Selegiline?
MediHelp rates the interaction as contraindicated. Buspirone and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline (an MAO-B inhibitor that loses selectivity at higher or transdermal doses) added to buspirone, a serotonin 5-HT1A partial agonist, has been associated with raised blood pressure and with serotonergic toxicity. Buspirone labelling advises against concurrent MAOI use.
How serious is the interaction between Buspirone and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Wait at least 14 days after stopping selegiline before starting the other drug.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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