Interazioni tra farmaci
Busulfan + Itraconazole
Gravità: Maggiore
Busulfan and Itraconazole: major interaction.
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Sintesi
Itraconazole can decrease busulfan clearance and raise its exposure. This may increase myelosuppression and hepatic veno-occlusive disease, which is of particular concern in transplant conditioning.
Cosa significa questa interazione in parole semplici
Busulfan and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Busulfan belongs to Oncology; Itraconazole belongs to Anti Fungals.
Perché avviene
Itraconazole inhibits CYP3A4 and glutathione-related busulfan metabolism, reducing busulfan clearance.
Cosa fare
Monitor busulfan levels where available and adjust the dose accordingly. Watch blood counts and liver function closely.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Itraconazole
- Alfuzosin + Itraconazole Controindicata
- Alprazolam + Itraconazole Controindicata
- Avanafil + Itraconazole Controindicata
- Conivaptan + Itraconazole Controindicata
- Dihydroergotamine intranasal + Itraconazole Controindicata
- Dihydroergotamine + Itraconazole Controindicata
Altre interazioni di Busulfan
- Busulfan + Carboplatin Maggiore
- Busulfan + Chlorambucil Maggiore
- Busulfan + Cyclophosphamide Maggiore
- Busulfan + Fingolimod Maggiore
- Busulfan + Hydroxyurea Maggiore
- Busulfan + Ifosfamide Maggiore
Domande frequenti
Can I take Busulfan with Itraconazole?
MediHelp rates the interaction as major. Busulfan and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole can decrease busulfan clearance and raise its exposure. This may increase myelosuppression and hepatic veno-occlusive disease, which is of particular concern in transplant conditioning.
How serious is the interaction between Busulfan and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor busulfan levels where available and adjust the dose accordingly. Watch blood counts and liver function closely.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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