Interazioni tra farmaci
Dihydroergotamine + Itraconazole
Gravità: Controindicata
Dihydroergotamine and Itraconazole: contraindicated interaction.
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Sintesi
Itraconazole markedly raises dihydroergotamine concentrations. This can cause serious ergotism with severe vasospasm and cerebral or limb ischemia.
Cosa significa questa interazione in parole semplici
Dihydroergotamine and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Perché avviene
Strong CYP3A4 inhibition by itraconazole reduces dihydroergotamine metabolism.
Cosa fare
Do not use together. Choose a non-ergot migraine therapy during and for a period after itraconazole.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Itraconazole
- Alfuzosin + Itraconazole Controindicata
- Alprazolam + Itraconazole Controindicata
- Avanafil + Itraconazole Controindicata
- Conivaptan + Itraconazole Controindicata
- Dihydroergotamine intranasal + Itraconazole Controindicata
- Disopyramide + Itraconazole Controindicata
Altre interazioni di Dihydroergotamine
- Almotriptan + Dihydroergotamine Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
- Dihydroergotamine + Dopamine Controindicata
- Dihydroergotamine + Dronedarone Controindicata
- Dihydroergotamine + Efavirenz Controindicata
- Dihydroergotamine + Eletriptan Controindicata
Domande frequenti
Can I take Dihydroergotamine with Itraconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole markedly raises dihydroergotamine concentrations. This can cause serious ergotism with severe vasospasm and cerebral or limb ischemia.
How serious is the interaction between Dihydroergotamine and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Choose a non-ergot migraine therapy during and for a period after itraconazole.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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