Interazioni tra farmaci
Dihydroergotamine intranasal + Itraconazole
Gravità: Controindicata
Dihydroergotamine intranasal and Itraconazole: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Itraconazole substantially increases systemic dihydroergotamine exposure even after intranasal dosing. This risks ergotism with serious vasospasm and ischemia.
Cosa significa questa interazione in parole semplici
Dihydroergotamine intranasal and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Strong CYP3A4 inhibition by itraconazole reduces dihydroergotamine metabolism.
Cosa fare
Do not combine. Use a non-ergot acute migraine treatment while on itraconazole.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Itraconazole
- Alfuzosin + Itraconazole Controindicata
- Alprazolam + Itraconazole Controindicata
- Avanafil + Itraconazole Controindicata
- Conivaptan + Itraconazole Controindicata
- Dihydroergotamine + Itraconazole Controindicata
- Disopyramide + Itraconazole Controindicata
Domande frequenti
Can I take Dihydroergotamine intranasal with Itraconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole substantially increases systemic dihydroergotamine exposure even after intranasal dosing. This risks ergotism with serious vasospasm and ischemia.
How serious is the interaction between Dihydroergotamine intranasal and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a non-ergot acute migraine treatment while on itraconazole.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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