Interazioni tra farmaci
Calcium / magnesium / potassium / sodium oxybates + Clorazepate
Gravità: Controindicata
Calcium / magnesium / potassium / sodium oxybates and Clorazepate: contraindicated interaction.
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Sintesi
Oxybates are potent CNS depressants, and with a benzodiazepine they can cause profound sedation, respiratory depression, coma and death. Use with sedatives is generally contraindicated or restricted by labeling.
Cosa significa questa interazione in parole semplici
Calcium / magnesium / potassium / sodium oxybates and Clorazepate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Additive CNS and respiratory depression via GABA-B and GABA-A mediated effects.
Cosa fare
Avoid the combination; if a benzodiazepine is essential, consider an alternative to the oxybate or stop one agent. If unavoidable, monitor closely for respiratory depression.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clorazepate
- Clorazepate + Sodium oxybate Controindicata
- Alfentanil + Clorazepate Maggiore
- Alprazolam + Clorazepate Maggiore
- Amobarbital + Clorazepate Maggiore
- Belladonna and opium + Clorazepate Maggiore
- Benzhydrocodone / acetaminophen + Clorazepate Maggiore
Domande frequenti
Can I take Calcium / magnesium / potassium / sodium oxybates with Clorazepate?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Clorazepate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybates are potent CNS depressants, and with a benzodiazepine they can cause profound sedation, respiratory depression, coma and death. Use with sedatives is generally contraindicated or restricted by labeling.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Clorazepate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if a benzodiazepine is essential, consider an alternative to the oxybate or stop one agent. If unavoidable, monitor closely for respiratory depression.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Sodium oxybate, Alfentanil, Alprazolam. The full list is on the Clorazepate page.
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