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Interazioni tra farmaci

Clorazepate + Sodium oxybate

Gravità: Controindicata

Clorazepate and Sodium oxybate: contraindicated interaction.

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Sintesi

Sodium oxybate is a potent CNS depressant, and with a benzodiazepine it can cause profound sedation, respiratory depression, coma and death. Labeling restricts concomitant use with sedatives.

Cosa significa questa interazione in parole semplici

Clorazepate and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Clorazepate belongs to Central Nervous System; Sodium oxybate belongs to Central Nervous System.

Livello di evidenza: High

Perché avviene

Additive CNS and respiratory depression via GABA-B and GABA-A mediated effects.

Cosa fare

Avoid the combination and choose an alternative to the benzodiazepine where possible. If unavoidable, monitor closely for respiratory depression.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Clorazepate with Sodium oxybate?

MediHelp rates the interaction as contraindicated. Clorazepate and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sodium oxybate is a potent CNS depressant, and with a benzodiazepine it can cause profound sedation, respiratory depression, coma and death. Labeling restricts concomitant use with sedatives.

How serious is the interaction between Clorazepate and Sodium oxybate?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative to the benzodiazepine where possible. If unavoidable, monitor closely for respiratory depression.

What other medicines interact with Clorazepate?

MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Clorazepate page.

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